I took Lariam in 2000 when I went to Zimbabwe to work and though I only bothered to take it for the first 6 weeks I didn't feel any kind of side effects, but that's just me. My friend who I went with didn't experience any problems either. I took 5-HTP and if you read up on the side effects of that you'll find people who talk about having increased dreams or nightmares and that is herbal medication!!
I stilll have the Consumer Information sheet Roche provides in the Lariam package and it states:
The following unwanted side effects have been reported to occur with Lariam: nausea, vomiting, dizziness, light-headedness or loss of balance, headache, sleepiness, inability to sleep, abnormal dreams, loose stools or diarrhea, and abdominal pain. In rarer cases, loss of appetite, abnormal heartbeat, itching of the skin or skin rash, hair loss, eyesight problems, mucle pains, convulsions, and disturbances of mood (depressed mood, mental confusion, anxiety states) may occur. Because many of these sysmptoms accompany malaria, it is often difficult to tell whether the symptons are due to malaria or are unwanted effects of 'Lariam'. When 'Lariam' is used as malaria prevention, these events usually subside within a short period of time after drug administration. If these adverse events are not severe in nature and are tolerable, it is in your best interest to continue 'Lariam' since the consequences of contracting malaria are cause for greater concern. It is best to avoid alcoloic drinks during treatment with 'Lariam'.
It also statesfor Special Precautions:
Lariam should not be used by:
1. Persons with a known sensitivity to mefloquine or related compounds. (Check with your Doctor).
2. Persons with a history of psychiatric disturbances.
3. Persons with a history of convulsions.
4. Persons suffering from severe liver or cardiac disease.
5. Woman who are or may become pregnant.
6. Nursing mothers
7. Children less then 3 yrs old.